A third person had been assessed at the scene and was not injured.
They sent a helicopter, an ambulance, a rapid response unit and a first response unit to the crash, which occurred near the intersection of SH1 and Mountain Rd, Kaiwaka, the spokeswoman said.
Photos from the scene show the crash appears to have happened at the location of a passing lane.
A car could be seen facing sideways on the left-hand side of the road with its front smashed in, and a ute with severe damage to its front passenger side could be seen straddling the middle of the road.
A truck was parked behind the car and a trailer could be seen behind the ute. Several people were shown standing or walking around the crash site.
The crash occurred on the section of state highway between Greenway and Mountain Rds and a part of the highway was closed, police said.
“[There are] diversions in place. Motorists should please avoid the area if possible, or expect delays.”
The section of road remained closed as of 1.15pm.
