Budget carriers including AirAsia X and Scoot have also introduced paid “quiet zones” where children under 12 are not allowed.
However, those measures have been limited to sections of aircraft rather than entire flights.
JetBlue is packaging these flights as part of a premium adults-only holiday rather than introducing blanket restrictions across its wider network.
It includes return flights between New York and Florida, followed by a four-night Virgin Voyages cruise next March.
Only 60 cabins are available, with prices starting at US$2750 (about $4830) for two guests.
Passengers will receive a complimentary alcoholic drink during the flight, along with lounge access, priority boarding, private transfers, a welcome party and a US$100 on-board bar tab per cabin.
The issue of child-free flying has long divided travellers. Calls for adults-only flights regularly resurface on social media, particularly after viral videos of disruptive children on board aircraft.

A 2017 survey by travel website Airfarewatchdog found more than half of respondents supported seating families with young children in separate sections of aircraft, while others said they would be willing to pay extra to sit away from children.
At the same time, critics have argued children and families have the same right to travel as anyone else and that dedicated child-free flights unfairly discriminate against parents.
Virgin Voyages chief executive Nirmal Saverimuttu said there is demand and they are filling it.
“People have wanted this kind of kid-free from takeoff to sail away for a long time, and now it actually exists,” Saverimuttu said.




